VENLAFAXINE HYDROCHLORIDE- venlafaxine hydrochloride capsule, extended release 
Greenstone LLC


Medication Guide

(venlafaxine hydrochloride)
(Extended-Release Capsules)

Read the Medication Guide that comes with venlafaxine hydrochloride extended-release before you start taking it and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or treatment. Talk with your healthcare provider if there is something you do not understand or want to learn more about.

What is the most important information I should know about venlafaxine hydrochloride extended-release?

Venlafaxine hydrochloride extended-release and other antidepressant medicines may cause serious side effects, including:

Suicidal thoughts or actions:

Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency. Venlafaxine hydrochloride extended-release may be associated with these serious side effects:

Serotonin Syndrome
This condition can be life-threatening and may include
  • agitation, hallucinations, coma or other changes in mental status
  • coordination problems or muscle twitching (overactive reflexes)
  • racing heartbeat, high or low blood pressure
  • sweating or fever
  • nausea, vomiting, or diarrhea
  • muscle rigidity
Changes in blood pressure. Venlafaxine hydrochloride extended-release may:
  • increase your blood pressure. Control high blood pressure before starting treatment and monitor blood pressure regularly
Enlarged pupils (mydriasis).
Anxiety and insomnia.
Changes in appetite or weight.
Manic/hypomanic episodes:
  • greatly increased energy
  • severe trouble sleeping
  • racing thoughts
  • reckless behavior
  • unusually grand ideas
  • excessive happiness or irritability
  • talking more or faster than usual
Low salt (sodium) levels in the blood. Elderly people may be at greater risk for this. Symptoms may include:
  • headache
  • weakness or feeling unsteady
  • confusion, problems concentrating or thinking or memory problems
Seizures or convulsions.
Abnormal bleeding: Venlafaxine hydrochloride extended-release and other antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAIDs, like ibuprofen or naproxen), or aspirin.
Elevated cholesterol.
Lung disease and pneumonia: venlafaxine hydrochloride extended-release may cause rare lung problems. Symptoms include:
  • worsening shortness of breath
  • cough
  • chest discomfort
Severe allergic reactions:
  • trouble breathing
  • swelling of the face, tongue, eyes or mouth
  • rash, itchy welts (hives) or blisters, alone or with fever or joint pain

Do not stop venlafaxine hydrochloride extended-release without first talking to your healthcare provider. Stopping venlafaxine hydrochloride extended-release too quickly or changing from another antidepressant too quickly may cause serious symptoms including:

What is venlafaxine hydrochloride extended-release?

Venlafaxine hydrochloride extended-release is a prescription medicine used to treat depression. It is important to talk with your healthcare provider about the risks of treating depression and also the risks of not treating it. You should discuss all treatment choices with your healthcare provider. Venlafaxine hydrochloride extended-release is also used to treat:

Talk to your healthcare provider if you do not think that your condition is getting better with venlafaxine hydrochloride extended-release treatment.

Who should not take venlafaxine hydrochloride extended-release?

Do not take venlafaxine hydrochloride extended-release if you:

What should I tell my healthcare provider before taking venlafaxine hydrochloride extended-release? Ask if you are not sure.

Before starting venlafaxine hydrochloride extended-release, tell your healthcare provider if you:

Tell your healthcare provider about all the medicines that you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. venlafaxine hydrochloride extended-release and some medicines may interact with each other, may not work as well, or may cause serious side effects.

Your healthcare provider or pharmacist can tell you if it is safe to take venlafaxine hydrochloride extended-release with your other medicines. Do not start or stop any medicine while taking venlafaxine hydrochloride extended-release without talking to your healthcare provider first.

If you take venlafaxine hydrochloride extended-release, you should not take any other medicines that contain (venlafaxine) including: venlafaxine HCl.

How should I take venlafaxine hydrochloride extended-release?

What should I avoid while taking venlafaxine hydrochloride extended-release?

Venlafaxine hydrochloride extended-release can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how venlafaxine hydrochloride extended-release affects you. Do not drink alcohol while using venlafaxine hydrochloride extended-release.

What are the possible side effects of Venlafaxine hydrochloride extended-release?

Venlafaxine hydrochloride extended-release may cause serious side effects, including:

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of venlafaxine hydrochloride extended-release. For more information, ask your healthcare provider or pharmacist.


How should I store venlafaxine hydrochloride extended-release?

Keep venlafaxine hydrochloride extended-release and all medicines out of the reach of children.

General information about venlafaxine hydrochloride extended-release

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use venlafaxine hydrochloride extended-release for a condition for which it was not prescribed. Do not give venlafaxine hydrochloride extended-release to other people, even if they have the same condition. It may harm them.

This Medication Guide summarizes the most important information about venlafaxine hydrochloride extended-release. If you would like more information, talk with your healthcare provider. You may ask your healthcare provider or pharmacist for information about Venlafaxine hydrochloride extended-release that is written for healthcare professionals.

What are the ingredients in venlafaxine hydrochloride extended-release?

Active ingredient: (venlafaxine)

Inactive ingredients:

This Medication Guide has been approved by the U.S. Food and Drug Administration for all antidepressants.

This product's label may have been updated. For current full prescribing information, please visit



Revised October 2016

Revised: 2/2018
Document Id: 63f3fd97-ad6e-4169-83db-8e41ca68e22e
Set id: 4c401522-0108-49cb-8a41-fb5ad4dd0fb1
Version: 32
Effective Time: 20180214
Greenstone LLC